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This webinar will focus on common parameters used for organism growth and protein purification with a focus on mixing/agitation, gas flow, chromatography and filtration scaling. Case studies will be presented to provide examples of an ideal scale-up scenario and a more creative solution to equipment adaptation problems as scale-up is not simply equations and multiplication but requires an understanding of how the equipment being used can impact the organism or protein, i.e. as mixing/agitation rates may not be a linear multiplication because the number of impellers present on the shaft generate different mixing profiles. By the end of the webinar, participants should have a general understanding of the concepts and tools required to successfully scale a process from bench to manufacturing.
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